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The battle against cancer is being fought on many fronts. Among the most cutting-edge research efforts are attempts to engineer nanotechnology-based therapies. To aid in this endeavor, the Nanotechnology Characterization Laboratory, part of the National Cancer Institute’s Alliance for Nanotechnology in Cancer and the National Cancer Institute at Frederick, has developed methods for nanoparticle…, E2524, , Test Method for Analysis of Hemolytic Properties of Nanoparticles, -E2524 is a protocol for examining the destruction of red blood cells (hemolysis) that can lead to anemia, jaundice and other issues. All intravenously administered drugs must be examined to determine potential for hemolysis. • , E2525, , Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage Colonies, -E2525 describes a method for evaluating nanoparticle stimulation or inhibition of the maturation of certain bone marrow cells (macrophages). A common side effect of anti-cancer drugs is inhibition of this process, and bone marrow cells may be particularly sensitive to nano-scale material. • , E2526, , Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials on Porcine Kidney Cells and Human Hepatocarcinoma Cells, -Because studies have indicated that many nanoparticles are cleared from the body through the kidney or liver, these organs are good choices for target organ toxicity evaluation. E2526 presents a method for evaluation of nanomaterial toxicity by examining effects on kidney and cancerous liver cells. Martin Fritts is senior principal scientist at the Nanotechnology Characterization Laboratory and…
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All interested parties are invited to attend a Sandwich Construction Workshop on Wednesday, March 12, at 4:30 p.m., in Melbourne, Fla. The workshop is being held by Subcommittee D30.09 on Sandwich Construction, part of ASTM International Committee D30 on Composite Materials. Committee D30 is meeting in conjunction with Marine Applications of Composite Materials from March 12-14 at the Crowne…
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A new ASTM International standard will enable composite end users and materials suppliers within the aerospace industry to perform an important test for polymer matrix composites within guidelines set by the U.S. Federal Aviation Administration. The standard, D7028 , Test Method for Glass Transition Temperature (DMA Tg) of Polymer Matrix Composites by Dynamic Mechanical Analysis (DMA), is under…
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Subcommittee D30.05 on Structural Test Methods, part of ASTM International Committee D30 on Composite Materials, has been standardizing a series of methods that are related to the analysis and substantiation of mechanically fastened joints composed of composite materials. The latest in this series of standards, D 7332/D 7332M , Test Method for Measuring the Fastener Pull-Through Resistance of a…
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ASTM International standards E 10 , Test Method for Brinell Hardness of Metallic Materials, and E 18 , Test Methods for Rockwell Hardness of Metallic Materials, have both recently undergone extensive revisions. Both standards are under the jurisdiction of Subcommittee E28.06 on Indentation Hardness Testing, which is part of ASTM International Committee E28 on Mechanical Testing. “The intention…
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ASTM International Committee E56 on Nanotechnology has approved its first standard, E 2456 , Terminology for Nanotechnology. The new standard is under the jurisdiction of Subcommittee E56.01 on Terminology and Nomenclature. Because of the great need for a terminology document that is globally recognized and because of the cooperation of several organizations in making the document a reality,…
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A new ASTM International standard will assist aerospace companies that are purchasing fine grain titanium alloys. The standard, E 2448, Test Method for Determining the Superplastic Properties of Metallic Sheet Materials, has been developed by ASTM Subcommittee E28.02 on Ductility and Flexure Testing, which is under the jurisdiction of Committee E28 on Mechanical Testing. According to Peter…
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Although ASTM International Committee E56 on Nanotechnology was just established this year, it has already begun an ambitious program of developing new standards. Committee E56 is currently developing the following proposed standards, which deal with environmental safety issues, hemolytic properties and particle size measurement. Interested parties are invited to participate in the development of…, WK8985, Guide for Handling Unbound Engineered Nanoparticles in Occupational Settings, Academic, government and industrial laboratories are currently performing nanotechnology research and development and the scope and breadth of this work is expected to grow dramatically. Manufacturing processes involving nanomaterials have begun and commercially available nano-based products have been introduced. All of this activity in the nanotechnology realm has created the need for the…, WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles, Subcommittee E56.02 on Characterization has begun working on proposed new standard WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles. This proposed standard would provide a suitable procedure for establishing the safety of nanoparticulate materials that will be used in vivo , such as nanoparticles for therapeutics and diagnostics. "Nanotechnology products will be used in…, For further technical information, contact Scott McNeil, director, Nanotechnology Characterization Laboratory, Frederick, Md. (phone: 301/846-6939; mcneils@ncifcrf.gov )., WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), Subcommittee E56.02 was formed to answer questions regarding characterization, such as size and shape of materials. Another proposed new standard under the jurisdiction of Subcommittee E56.02 is WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), which deals with the vital issue of size characterization. The purpose of the…
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ASTM International Committee D30 on Composite Materials invites all interested parties to participate in a new task group on fiber-reinforced polymers. The task group is under the jurisdiction of Subcommittee D30.05 on Structural Test Methods. The purpose of the new task group is to review a series of tests that the American Concrete Institute has developed through their Committee 440 on Fiber-…
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A questionnaire sent to members of ASTM International Committee D30 on Composite Materials proved to be the catalyst for a pair of newly approved standards, D 7136, Test Method Measuring the Damage Resistance of a Fiber-Reinforced Polymer Matrix Composite to a Drop-Weight Impact Event, and D 7137, Test Method for Compressive Residual Strength Properties of Damaged Polymer Matrix Composite Plates…