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The battle against cancer is being fought on many fronts. Among the most cutting-edge research efforts are attempts to engineer nanotechnology-based therapies. To aid in this endeavor, the Nanotechnology Characterization Laboratory, part of the National Cancer Institute’s Alliance for Nanotechnology in Cancer and the National Cancer Institute at Frederick, has developed methods for nanoparticle…, E2524, , Test Method for Analysis of Hemolytic Properties of Nanoparticles, -E2524 is a protocol for examining the destruction of red blood cells (hemolysis) that can lead to anemia, jaundice and other issues. All intravenously administered drugs must be examined to determine potential for hemolysis. • , E2525, , Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage Colonies, -E2525 describes a method for evaluating nanoparticle stimulation or inhibition of the maturation of certain bone marrow cells (macrophages). A common side effect of anti-cancer drugs is inhibition of this process, and bone marrow cells may be particularly sensitive to nano-scale material. • , E2526, , Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials on Porcine Kidney Cells and Human Hepatocarcinoma Cells, -Because studies have indicated that many nanoparticles are cleared from the body through the kidney or liver, these organs are good choices for target organ toxicity evaluation. E2526 presents a method for evaluation of nanomaterial toxicity by examining effects on kidney and cancerous liver cells. Martin Fritts is senior principal scientist at the Nanotechnology Characterization Laboratory and…
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All interested parties are invited to participate in a new task group on instrument test results for sensory evaluation of consumer products, including food and cosmetics. The new task group will be part of ASTM International Committee E18 on Sensory Evaluation and will meet during the E18 meetings at April committee week in Anaheim, Calif. “Our goal at this meeting will be to recruit members,…
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Cyanide is routinely analyzed in water samples, often to demonstrate regulatory compliance; however, improper sample collection or pretreatment can result in significant positive or negative bias potentially resulting in unnecessary permit violations or undetected cyanide releases into the environment. Because of the importance and timeliness of these issues, ASTM Subcommittee D19.06 on Methods…
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While nearly all of the instrumentation employed in the field to measure radioactive materials or radiation exposure rates used to be in the hands of state radiological control agencies or federal government national response organizations, this is no longer the case. Now, law enforcement personnel, first responders and other professionals have radiation detection instruments, though they may not…
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ASTM International Committee D19 on Water will host a workshop on turbidity during the June Committee Week in Norfolk, Va. Subcommittee D19.07 on Sediment, Geomorphology and Open Channel Flow will present the workshop from 1:00 to 5:00 p.m. on June 26, 2007. According to Mike Sadar, D19 member and principal application scientist, Hach Company, Committee D19 has invested several years in the…
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ASTM International Committee E18 on Sensory Evaluation has been working on developing a series of widely used, fundamental discrimination tests into ASTM International standards. Some of these tests that are now approved standards include E2263 , Standard Test Method for Paired Preference Test, E 2139, Test Method for Same-Different Test, and E 1885 , Test Method for Sensory Analysis-Triangle…
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ASTM International Committee E56 on Nanotechnology has approved its first standard, E 2456 , Terminology for Nanotechnology. The new standard is under the jurisdiction of Subcommittee E56.01 on Terminology and Nomenclature. Because of the great need for a terminology document that is globally recognized and because of the cooperation of several organizations in making the document a reality,…
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Although ASTM International Committee E56 on Nanotechnology was just established this year, it has already begun an ambitious program of developing new standards. Committee E56 is currently developing the following proposed standards, which deal with environmental safety issues, hemolytic properties and particle size measurement. Interested parties are invited to participate in the development of…, WK8985, Guide for Handling Unbound Engineered Nanoparticles in Occupational Settings, Academic, government and industrial laboratories are currently performing nanotechnology research and development and the scope and breadth of this work is expected to grow dramatically. Manufacturing processes involving nanomaterials have begun and commercially available nano-based products have been introduced. All of this activity in the nanotechnology realm has created the need for the…, WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles, Subcommittee E56.02 on Characterization has begun working on proposed new standard WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles. This proposed standard would provide a suitable procedure for establishing the safety of nanoparticulate materials that will be used in vivo , such as nanoparticles for therapeutics and diagnostics. "Nanotechnology products will be used in…, For further technical information, contact Scott McNeil, director, Nanotechnology Characterization Laboratory, Frederick, Md. (phone: 301/846-6939; mcneils@ncifcrf.gov )., WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), Subcommittee E56.02 was formed to answer questions regarding characterization, such as size and shape of materials. Another proposed new standard under the jurisdiction of Subcommittee E56.02 is WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), which deals with the vital issue of size characterization. The purpose of the…
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ASTM International Committee E18 on Sensory Evaluation of Materials and Products is currently working on a proposed new standard, WK8435, Practice/Guide for Measuring and Tracking Sensory Descriptive Panel and Panelist Performance. WK8435 will be used to assist sensory professionals in selecting, screening, and identifying training needs for new and existing panels and assessors. In addition,…
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ASTM Committee E18 on Sensory Evaluation of Materials and Products is currently working on a proposed new standard that outlines the experience and education necessary to become a sensory professional. The proposed standard, WK7661, is tentatively titled Guide for Sensory Proficiency, and is under the jurisdiction of Subcommittee E18.05 on Sensory Applications General -- General . According to…