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The battle against cancer is being fought on many fronts. Among the most cutting-edge research efforts are attempts to engineer nanotechnology-based therapies. To aid in this endeavor, the Nanotechnology Characterization Laboratory, part of the National Cancer Institute’s Alliance for Nanotechnology in Cancer and the National Cancer Institute at Frederick, has developed methods for nanoparticle…, E2524, , Test Method for Analysis of Hemolytic Properties of Nanoparticles, -E2524 is a protocol for examining the destruction of red blood cells (hemolysis) that can lead to anemia, jaundice and other issues. All intravenously administered drugs must be examined to determine potential for hemolysis. • , E2525, , Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage Colonies, -E2525 describes a method for evaluating nanoparticle stimulation or inhibition of the maturation of certain bone marrow cells (macrophages). A common side effect of anti-cancer drugs is inhibition of this process, and bone marrow cells may be particularly sensitive to nano-scale material. • , E2526, , Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials on Porcine Kidney Cells and Human Hepatocarcinoma Cells, -Because studies have indicated that many nanoparticles are cleared from the body through the kidney or liver, these organs are good choices for target organ toxicity evaluation. E2526 presents a method for evaluation of nanomaterial toxicity by examining effects on kidney and cancerous liver cells. Martin Fritts is senior principal scientist at the Nanotechnology Characterization Laboratory and…
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ASTM International Committee E35 on Pesticides and Alternative Control Agents has begun work on the latest in a series of standards on biofilm. The proposed new standard, WK17813 , Test Method for Quantification of a, Pseudomonas aeruginosa, Biofilm Grown with Low Shear and Continuous Flow Using a Drip Flow Biofilm Reactor, is being developed by Subcommittee E35.15 on Antimicrobial Agents. According to Darla M. Goeres, senior research engineer, Center for Biofilm Engineering, and E35 member, biofilm is defined as microorganisms living in a self-organized cooperative community. These communities, which are embedded in slime and can be…, Pseudomonas aeruginosa, Biofilm Grown with High Shear and Continuous Flow Using CDC Biofilm Reactor; and E2196 , Test Method for Quantification of a, Pseudomonas aeruginosa, Biofilm Grown with Shear and Continuous Flow Using a Rotating Disk Reactor) is that biofilm is grown under low fluid shear close to the air/liquid interface and that the drip flow reactor is a plug flow reactor system, resulting in biofilm that is visible to the naked eye and smooth and slimy in appearance. Biofilm generated in a drip flow reactor could represent those found in a wide spectrum of…
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Automotive companies and interior suppliers will be the primary users of a proposed new ASTM International standard that will aid in testing of automotive interior materials and parts, draperies or other applications in which durability behind glass is desired. The proposed standard, WK16895 , Practice for Conducting Exposures in Outdoor Glass-Covered Exposure Apparatus with Air Recirculation, is…
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Biofilm, self-organized communities of bacteria that can have both positive and negative effects in a variety of industries, is the subject of a new ASTM International standard, E 2562 , Test Method for Quantification of Pseudomonas aeruginosa Biofilm Grown with High Shear and Continuous Flow Using CDC Biofilm Reactor. The new standard is under the jurisdiction of Subcommittee E35.15 on…
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Responding to a new emphasis by regulatory agencies that firms manufacturing drug products demonstrate the efficacy of disinfectants used in controlled environments, ASTM International Committee E35 on Pesticides and Alternative Control Agents has begun to develop a proposed new standard, WK12880 , Guide for Evaluation of Clean Room Disinfectants. WK12880 is under the jurisdiction of Subcommittee…
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ASTM International Committee E56 on Nanotechnology has approved its first standard, E 2456 , Terminology for Nanotechnology. The new standard is under the jurisdiction of Subcommittee E56.01 on Terminology and Nomenclature. Because of the great need for a terminology document that is globally recognized and because of the cooperation of several organizations in making the document a reality,…
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A new standard developed by ASTM International Committee F37 on Light Sport Aircraft covers the instructions a kit producer must provide to a consumer regarding how to assemble and safely flight-test a recreational aircraft to ensure compliance with applicable ASTM standards. The new standard, F 2563 , Practice for Kit Assembly Instructions of Aircraft Intended Primarily for Recreation, is under…
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Although ASTM International Committee E56 on Nanotechnology was just established this year, it has already begun an ambitious program of developing new standards. Committee E56 is currently developing the following proposed standards, which deal with environmental safety issues, hemolytic properties and particle size measurement. Interested parties are invited to participate in the development of…, WK8985, Guide for Handling Unbound Engineered Nanoparticles in Occupational Settings, Academic, government and industrial laboratories are currently performing nanotechnology research and development and the scope and breadth of this work is expected to grow dramatically. Manufacturing processes involving nanomaterials have begun and commercially available nano-based products have been introduced. All of this activity in the nanotechnology realm has created the need for the…, WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles, Subcommittee E56.02 on Characterization has begun working on proposed new standard WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles. This proposed standard would provide a suitable procedure for establishing the safety of nanoparticulate materials that will be used in vivo , such as nanoparticles for therapeutics and diagnostics. "Nanotechnology products will be used in…, For further technical information, contact Scott McNeil, director, Nanotechnology Characterization Laboratory, Frederick, Md. (phone: 301/846-6939; mcneils@ncifcrf.gov )., WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), Subcommittee E56.02 was formed to answer questions regarding characterization, such as size and shape of materials. Another proposed new standard under the jurisdiction of Subcommittee E56.02 is WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), which deals with the vital issue of size characterization. The purpose of the…
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Executives from the Federal Aviation Administration (FAA) met with ASTM International members and staff at this years Airventure - a premier show and convention in the aviation world, hosted by the Experimental Aircraft Association (EAA). The briefing provided an update to the FAA on the status of ASTMs standards initiatives in the aviation sector. Among the representatives for the…
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Open Meetings and One-Day Workshop in May, The National Institute of Advanced Industrial Science and Technology (AIST) in Japan has become the latest organization to sign a partnership agreement with ASTM International to develop a terminology standard for nanotechnology. AIST is an Independent Administrative Institution (IAI) in association with the Japanese Ministry of Economy, Trade and Industry (METI). AIST represents an amalgamation…, Partnerships Prove Beneficial, An early priority for the recently formed ASTM International Committee E56 on Nanotechnology is the development of a globally relevant, industry-driven terminology standard. In an effort to facilitate this objective, ASTM International has signed partnership agreements with the Institute of Electrical & Electronics Engineers (IEEE), the American Society of Mechanical Engineers (ASME), NSF…, Attendance Encouraged at Open Meetings and Workshop, Interested individuals are encouraged to attend the next meeting of Committee E56, which will take place May 16-18, 2005, in Reno, Nev., at the Hilton Reno Resort. Following the meetings, on May 19, at the same hotel, Committee E56 will cosponsor a Workshop on Characterization of Nanomaterials for Medical and Health Applications. The workshop will provide a structured venue to address critical…