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A revision to an important ASTM nanotechnology standard incorporates a large-scale interlaboratory study that took place in 2008. The revised standard, ASTM E2490 , Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), is under the jurisdiction of Subcommittee E56.02 on Characterization: Physical, Chemical and Toxicological…
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Outbreaks of the H1N1 influenza this year have increased the public’s awareness and use of leave-on hand antiseptics, popularly known as hand sanitizers. ASTM International Committee E35 on Pesticides and Alternative Control Agents is now developing a proposed new standard that will measure the antibacterial activity of hand sanitizers on people’s hands. ASTM WK23789 , Test Method for Evaluation…
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Biofilm, which is defined as microorganisms living in a self-organized cooperative community, is still under the radar for many industry, medical, professional and regulatory agencies. A newly approved ASTM International standard is the latest in a series of biofilm standards being developed by Committee E35 on Pesticides and Alternative Control Agents. The new standard, E2647 , Test Method for…
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ASTM International Committee E35 on Pesticides and Alternative Control Agents has now published the last in a series of three ASTM International standards that address the activity of hand hygiene agents against microbes that can be transmitted via contaminated hands. Subcommittee E35.15 on Antimicrobial Agents developed the new standard, ASTM E2613 , Test Method for Determining Fungus-…
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A workshop on the role of standards in the emerging field of nanotechnology will be held Oct. 8-9, 2008, at the National Institute of Standards and Technology near Washington, D.C. The workshop, "Enabling Standards for Nanomaterial Characterization," is being co-sponsored by the National Cancer Institute's Nanotechnology Characterization Laboratory, the National Institute of Standards and…
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The battle against cancer is being fought on many fronts. Among the most cutting-edge research efforts are attempts to engineer nanotechnology-based therapies. To aid in this endeavor, the Nanotechnology Characterization Laboratory, part of the National Cancer Institute’s Alliance for Nanotechnology in Cancer and the National Cancer Institute at Frederick, has developed methods for nanoparticle…, E2524, , Test Method for Analysis of Hemolytic Properties of Nanoparticles, -E2524 is a protocol for examining the destruction of red blood cells (hemolysis) that can lead to anemia, jaundice and other issues. All intravenously administered drugs must be examined to determine potential for hemolysis. • , E2525, , Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage Colonies, -E2525 describes a method for evaluating nanoparticle stimulation or inhibition of the maturation of certain bone marrow cells (macrophages). A common side effect of anti-cancer drugs is inhibition of this process, and bone marrow cells may be particularly sensitive to nano-scale material. • , E2526, , Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials on Porcine Kidney Cells and Human Hepatocarcinoma Cells, -Because studies have indicated that many nanoparticles are cleared from the body through the kidney or liver, these organs are good choices for target organ toxicity evaluation. E2526 presents a method for evaluation of nanomaterial toxicity by examining effects on kidney and cancerous liver cells. Martin Fritts is senior principal scientist at the Nanotechnology Characterization Laboratory and…
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ASTM International Committee E35 on Pesticides and Alternative Control Agents has begun work on the latest in a series of standards on biofilm. The proposed new standard, WK17813 , Test Method for Quantification of a, Pseudomonas aeruginosa, Biofilm Grown with Low Shear and Continuous Flow Using a Drip Flow Biofilm Reactor, is being developed by Subcommittee E35.15 on Antimicrobial Agents. According to Darla M. Goeres, senior research engineer, Center for Biofilm Engineering, and E35 member, biofilm is defined as microorganisms living in a self-organized cooperative community. These communities, which are embedded in slime and can be…, Pseudomonas aeruginosa, Biofilm Grown with High Shear and Continuous Flow Using CDC Biofilm Reactor; and E2196 , Test Method for Quantification of a, Pseudomonas aeruginosa, Biofilm Grown with Shear and Continuous Flow Using a Rotating Disk Reactor) is that biofilm is grown under low fluid shear close to the air/liquid interface and that the drip flow reactor is a plug flow reactor system, resulting in biofilm that is visible to the naked eye and smooth and slimy in appearance. Biofilm generated in a drip flow reactor could represent those found in a wide spectrum of…
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Biofilm, self-organized communities of bacteria that can have both positive and negative effects in a variety of industries, is the subject of a new ASTM International standard, E 2562 , Test Method for Quantification of Pseudomonas aeruginosa Biofilm Grown with High Shear and Continuous Flow Using CDC Biofilm Reactor. The new standard is under the jurisdiction of Subcommittee E35.15 on…
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Responding to a new emphasis by regulatory agencies that firms manufacturing drug products demonstrate the efficacy of disinfectants used in controlled environments, ASTM International Committee E35 on Pesticides and Alternative Control Agents has begun to develop a proposed new standard, WK12880 , Guide for Evaluation of Clean Room Disinfectants. WK12880 is under the jurisdiction of Subcommittee…
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ASTM International Committee E56 on Nanotechnology has approved its first standard, E 2456 , Terminology for Nanotechnology. The new standard is under the jurisdiction of Subcommittee E56.01 on Terminology and Nomenclature. Because of the great need for a terminology document that is globally recognized and because of the cooperation of several organizations in making the document a reality,…