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The battle against cancer is being fought on many fronts. Among the most cutting-edge research efforts are attempts to engineer nanotechnology-based therapies. To aid in this endeavor, the Nanotechnology Characterization Laboratory, part of the National Cancer Institute’s Alliance for Nanotechnology in Cancer and the National Cancer Institute at Frederick, has developed methods for nanoparticle…, E2524, , Test Method for Analysis of Hemolytic Properties of Nanoparticles, -E2524 is a protocol for examining the destruction of red blood cells (hemolysis) that can lead to anemia, jaundice and other issues. All intravenously administered drugs must be examined to determine potential for hemolysis. • , E2525, , Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage Colonies, -E2525 describes a method for evaluating nanoparticle stimulation or inhibition of the maturation of certain bone marrow cells (macrophages). A common side effect of anti-cancer drugs is inhibition of this process, and bone marrow cells may be particularly sensitive to nano-scale material. • , E2526, , Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials on Porcine Kidney Cells and Human Hepatocarcinoma Cells, -Because studies have indicated that many nanoparticles are cleared from the body through the kidney or liver, these organs are good choices for target organ toxicity evaluation. E2526 presents a method for evaluation of nanomaterial toxicity by examining effects on kidney and cancerous liver cells. Martin Fritts is senior principal scientist at the Nanotechnology Characterization Laboratory and…
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A new ASTM International standard that covers annular ball bearings intended primarily for use in instrument and precision rotating components has been developed as a conversion of a U.S. military standard, MIL-B-81793F, Annular Ball Bearings, for Instruments and Precision Rotating Components. The new standard, F 2332 , Specification for Annular Ball Bearings for Instruments and Precision…
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Users of laboratory services and other interested parties are invited to participate in the development of a new practice that will promote uniformity in quality management practice for all standards under the jurisdiction of ASTM International Committee D05 on Coal and Coke. Subcommittee D05.30 on Quality Assurance is developing the proposed new standard, WK14563 , Establishing the Competence of…
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ASTM International Committee E56 on Nanotechnology has approved its first standard, E 2456 , Terminology for Nanotechnology. The new standard is under the jurisdiction of Subcommittee E56.01 on Terminology and Nomenclature. Because of the great need for a terminology document that is globally recognized and because of the cooperation of several organizations in making the document a reality,…
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Sampling is a difficult but essential part of the coal production process. ASTM International Committee D05 on Coal and Coke hopes to streamline that process with the publication of new standard D 7256/D 7256M, Practice for Mechanical Collection and Within-System Preparation of a Gross Sample of Coal from Moving Streams. Practice D 7256/D 7256M is under the jurisdiction of Subcommittee D05.23 on…
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ASTM International Committee D05 on Coal and Coke is currently seeking participation in the development of a proposed new standard, WK10700 , Test Method for Total Moisture in Coal Reduced to 2.36 mm (No. 8 Sieve) Topsize Through Determination of Air-Drying Loss by Microwave Oven. The proposed new standard is under the jurisdiction of Subcommittee D05.21 on Methods of Analysis. While air-drying…
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ASTM Committee D05 on Coal and Coke is currently developing a proposed new standard, WK10380, Practice for Establishing the Competence of Laboratories Using ASTM Procedures in the Sampling and Analysis of Coal and Coke. The proposed standard will specify requirements for establishing, operating and evaluating a laboratory that provides services in the areas of sample collection and preparation…
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Most of the coal burned in the United States contains only trace amounts of chloride and fluoride. However, due to the increasing regulation of these compounds for clean air initiatives, being able to measure even small amounts of chloride and fluoride in coal has taken on a greater importance than ever. Recognizing this, ASTM International Committee D05 on Coal and Coke has begun to develop a…
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ASTM International Committee D05 on Coal and Coke is seeking participation in the development of a proposed new standard, WK9165, Test Methods for Loss on Ignition of Solid Combustion Residues. According to John Riley, a recently retired chemistry professor at Western Kentucky University, the question of how loss on ignition testing is done is an issue that a task group he chairs began looking at…
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Although ASTM International Committee E56 on Nanotechnology was just established this year, it has already begun an ambitious program of developing new standards. Committee E56 is currently developing the following proposed standards, which deal with environmental safety issues, hemolytic properties and particle size measurement. Interested parties are invited to participate in the development of…, WK8985, Guide for Handling Unbound Engineered Nanoparticles in Occupational Settings, Academic, government and industrial laboratories are currently performing nanotechnology research and development and the scope and breadth of this work is expected to grow dramatically. Manufacturing processes involving nanomaterials have begun and commercially available nano-based products have been introduced. All of this activity in the nanotechnology realm has created the need for the…, WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles, Subcommittee E56.02 on Characterization has begun working on proposed new standard WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles. This proposed standard would provide a suitable procedure for establishing the safety of nanoparticulate materials that will be used in vivo , such as nanoparticles for therapeutics and diagnostics. "Nanotechnology products will be used in…, For further technical information, contact Scott McNeil, director, Nanotechnology Characterization Laboratory, Frederick, Md. (phone: 301/846-6939; mcneils@ncifcrf.gov )., WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), Subcommittee E56.02 was formed to answer questions regarding characterization, such as size and shape of materials. Another proposed new standard under the jurisdiction of Subcommittee E56.02 is WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), which deals with the vital issue of size characterization. The purpose of the…