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The battle against cancer is being fought on many fronts. Among the most cutting-edge research efforts are attempts to engineer nanotechnology-based therapies. To aid in this endeavor, the Nanotechnology Characterization Laboratory, part of the National Cancer Institute’s Alliance for Nanotechnology in Cancer and the National Cancer Institute at Frederick, has developed methods for nanoparticle…, E2524, , Test Method for Analysis of Hemolytic Properties of Nanoparticles, -E2524 is a protocol for examining the destruction of red blood cells (hemolysis) that can lead to anemia, jaundice and other issues. All intravenously administered drugs must be examined to determine potential for hemolysis. • , E2525, , Test Method for Evaluation of the Effect of Nanoparticulate Materials on the Formation of Mouse Granulocyte-Macrophage Colonies, -E2525 describes a method for evaluating nanoparticle stimulation or inhibition of the maturation of certain bone marrow cells (macrophages). A common side effect of anti-cancer drugs is inhibition of this process, and bone marrow cells may be particularly sensitive to nano-scale material. • , E2526, , Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials on Porcine Kidney Cells and Human Hepatocarcinoma Cells, -Because studies have indicated that many nanoparticles are cleared from the body through the kidney or liver, these organs are good choices for target organ toxicity evaluation. E2526 presents a method for evaluation of nanomaterial toxicity by examining effects on kidney and cancerous liver cells. Martin Fritts is senior principal scientist at the Nanotechnology Characterization Laboratory and…
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ASTM International Committee F24 on Amusement Rides and Devices will celebrate its 30th anniversary this year, marking its significant contributions to the global amusement industry. ASTM is one of the largest voluntary standards development organizations in the world., F24 Standards: The Foundation for Safe Fun, Since 1978, ASTM Committee F24 has developed the standards that are the underpinning of safety for amusement rides and attractions around the world. During the past three decades, Committee F24 has contributed a comprehensive range of standards that cover design, manufacturing, maintenance, inspection and operations across traditional amusement rides, specialty rides and attractions, and water-…, F24: Global Experts Developing Internationally Accepted Standards, ASTM Committee F24 brings together global amusement industry stakeholders in a best-in-class standards development forum. Today, F24 comprises approximately 500 professionals from 23 countries across North America, South America, Europe and Asia. F24 members include ride designers and manufacturers, engineers, technicians, regulators, inspectors, park owners and operators, consumer advocacy…, Supporting Ride Innovation and Amusement Growth, As new categories of amusement rides have been introduced and grown in popularity, ASTM Committee F24 has kept pace by addressing emerging requirements for standards. In the last several years, new F24 subcommittees have been formed to address growth in areas such as water rides as well as specialty attractions like go-karts, inflatable amusement devices and bumper boats., A Model of Industry Cooperation, To help to establish worldwide consistency in major areas of ride safety standards, ASTM Committee F24 works in close partnership with other representative organizations of the global amusement industry, such as the International Association of Amusement Parks and Attractions (IAAPA). ASTM F24 and IAAPA bring together representatives from industry and standards bodies from around the world for…
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Drawing on the best practices of the U.S. Federal Highway Administration and the states, ASTM International Committee E17 on Vehicle-Pavement Systems has developed a new standard, E 2561 , Practice for Installation of Inductive Loop Detectors. E 2561 is under the jurisdiction of Subcommittee E17.52 on Traffic Monitoring. Inductive loop detectors are installed in sawed slots in roadway pavement…
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Airport operators, military pavement maintenance personnel, transportation regulatory agencies and state highway departments will all benefit from the approval of a new ASTM standard for measuring skid resistance. The standard, E 2340 , Test Method for Measuring the Skid Resistance of Pavements and Other Trafficked Surfaces Using a Continuous Reading, Fixed-Slip Technique, was developed by…
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Two new standards developed by ASTM International Committee E17 on Vehicle Pavement Systems will provide uniform specification and test criteria for agencies and manufacturers that deal with traffic monitoring devices. The new standards, which are both under the jurisdiction of Subcommittee E17.52 on Traffic Monitoring, are E 2300 , Specification for Highway Traffic Monitoring Devices, and E 2532…
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ASTM International Committee E56 on Nanotechnology has approved its first standard, E 2456 , Terminology for Nanotechnology. The new standard is under the jurisdiction of Subcommittee E56.01 on Terminology and Nomenclature. Because of the great need for a terminology document that is globally recognized and because of the cooperation of several organizations in making the document a reality,…
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The rapid growth and variety of rides being developed within the water park industry has created a need for new standards to regulate the design and installation of water slides. While individual states within the United States had created rules and guidelines for water slides, these often varied greatly from each other. A new standard developed by ASTM International Committee F24 on Amusement…
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A more efficient method to take asphalt pavement layer temperatures is the subject of a new standard developed by Subcommittee E17.41 on Pavement Management. The document, D 7228 , Test Method for Prediction of Asphalt-Bound Pavement Layer Temperatures, details surface temperature measurement and is based on temperature relationships in the Federal Highway Administration Long Term Pavement…
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Many state departments of transportation are collecting traffic data in real time and using it to manage traffic or provide travel information, as part of intelligent transportation systems. Some agencies save and archive this data after its initial real-time use and make it available to other data users, who often know little about how the data was collected or even what is contained in the data…
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Although ASTM International Committee E56 on Nanotechnology was just established this year, it has already begun an ambitious program of developing new standards. Committee E56 is currently developing the following proposed standards, which deal with environmental safety issues, hemolytic properties and particle size measurement. Interested parties are invited to participate in the development of…, WK8985, Guide for Handling Unbound Engineered Nanoparticles in Occupational Settings, Academic, government and industrial laboratories are currently performing nanotechnology research and development and the scope and breadth of this work is expected to grow dramatically. Manufacturing processes involving nanomaterials have begun and commercially available nano-based products have been introduced. All of this activity in the nanotechnology realm has created the need for the…, WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles, Subcommittee E56.02 on Characterization has begun working on proposed new standard WK8997, Practice for Analysis of Hemolytic Properties of Nanoparticles. This proposed standard would provide a suitable procedure for establishing the safety of nanoparticulate materials that will be used in vivo , such as nanoparticles for therapeutics and diagnostics. "Nanotechnology products will be used in…, For further technical information, contact Scott McNeil, director, Nanotechnology Characterization Laboratory, Frederick, Md. (phone: 301/846-6939; mcneils@ncifcrf.gov )., WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), Subcommittee E56.02 was formed to answer questions regarding characterization, such as size and shape of materials. Another proposed new standard under the jurisdiction of Subcommittee E56.02 is WK8705, Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS), which deals with the vital issue of size characterization. The purpose of the…